Ryan M. Pearson PhD

Research Project:
Using Nanoparticles to Target and Reprogram Immune Cell Metabolism to Treat Asthma

Grant Awarded:

Innovation Award

Research Topics:

combination therapies experimental therapeutics
immunology immunotherapy

Research Diseases:

allergy
asthma

Asthma is a chronic lung disease driven by an overactive immune system. It leads to airway inflammation, mucus production and difficulty breathing. Current treatments often suppress the immune system broadly, increasing the risk of infections. Our research focuses on a novel approach using tiny biodegradable particles called nanoparticles (NPs) to target and reprogram immune cell metabolism. These NPs are engineered to carry allergens, helping the body build tolerance by reducing harmful immune responses without weakening the entire immune system. By leveraging the body’s natural metabolic processes, our strategy aims to restore balance in the lungs to prevent and treat asthma more safely and effectively. This innovative approach could pave the way for personalized therapies that boost tolerance for many allergens and reduce allergic responses. This would improve the quality of life for millions of people with asthma and related lung diseases.

The Charles and Amelia Gould Innovation Award

Page last updated: October 30, 2025

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